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| Episode 1 - [One Bad Night And CHAOS Of Selfish Desires] |
| Details : Sheldon and Missy both run away from home and Mary gets upsetting news about George Sr. |
| Guest Cast and Crew : Tom Yi as Dr. Kwok | Ava Allan as Jana Boggs | Wallace Shawn as John Sturgis | Melissa Peterman as Brenda Sparks | Director : Alex Reid | |
| Air Date : Oct. 07, 2021 | Rating ➦ ★★★★★★ |
| Episode 2 - [Snoopin' Around And The Wonder Twins Of Atheism] |
| Details : Sheldon encourages Missy to question the Bible. Also Connie is determined to catch George Sr. in a lie and Mary helps Pastor Jeff search for a youth pastor. |
| Guest Cast and Crew : José Antonio García as Nick | Andrew Patrick Ralston as Pastor Steve | Mason McCulley as Pastor Andy | Bobo Chang as Pastor Charlie | Nancy Linehan Charles as Peg | Dan Byrd as Rob | Doc Farrow as Wayne Wilkins | Melissa Peterman as Brenda Sparks | Director : Michael Judd | |
| Air Date : Oct. 14, 2021 | Rating ➦ ★★★★★★ |
| Episode 3 - [Potential Energy And Hooch On A Park Bench] |
| Details : Sheldon tries to convince Dr. Sturgis to return to the university. Also Georgie upsets the family when he makes a life-changing decision. |
| Guest Cast and Crew : Anthony M. Bertram as Officer Smith | Ava Allan as Jana Boggs | Wallace Shawn as John Sturgis | Craig T. Nelson as Dale Ballard | Ed Begley Jr. as Grant Linkletter | Doc Farrow as Wayne Wilkins | Rex Linn as Tom Petersen | Director : Nikki Lorre | |
| Air Date : Oct. 21, 2021 | Rating ➦ ★★★★★★ |
| Episode 4 - [Pish Posh And A Secret Back Room] |
| Details : Sheldon Missy and Georgie adapt to new living arrangements. Also Connie opens a gambling room. |
| Guest Cast and Crew : Frank Collison as Chet | Valeri Ross as Harriet | Audrey Wasilewski as Joann | Tony Winters as Conductor | Bill Fagerbakke as Jake | Craig T. Nelson as Dale Ballard | Director : Alex Reid | |
| Air Date : Oct. 28, 2021 | Rating ➦ ★★★★★★★ |
| Episode 5 - [Stuffed Animals And A Sweet Southern Syzygy] |
| Details : Sheldon and Dr. Linkletter struggle to solve an equation. Also Georgie has a solution for Connie's business woes and George Sr. gives advice on Missy's love life. |
| Guest Cast and Crew : Donna Pieroni as Female Patron | Wallace Shawn as John Sturgis | Craig T. Nelson as Dale Ballard | Ed Begley Jr. as Grant Linkletter | Doc Farrow as Wayne Wilkins | Melissa Peterman as Brenda Sparks | Director : Jeremy Howe | |
| Air Date : Nov. 04, 2021 | Rating ➦ ★★★★★★ |
| Episode 6 - [Money Laundering And A Cascade Of Hormones] |
| Details : Missy asks some uncomfortable questions at church and Connie and Georgie go into business together. |
| Guest Cast and Crew : Andy Forrest as Manager | Bill Fagerbakke as Jake | Benjamin Royer as Andy | Nancy Linehan Charles as Peg | Wallace Shawn as John Sturgis | Craig T. Nelson as Dale Ballard | Dan Byrd as Rob | Grady Lee Richmond as Wade | Director : Nikki Lorre | |
| Air Date : Nov. 11, 2021 | Rating ➦ ★★★★★★★ |
| Episode 7 - [An Introduction To Engineering And A Glob Of Hair Gel] |
| Details : Sheldon takes his first engineering class with Professor Boucher. Also Meemaw and Dale help take care of his ex-wife June. |
| Guest Cast and Crew : Lance Reddick as Professor Boucher | Simon Helberg as Howard Wolowitz (voice) | Reba McEntire as June | Craig T. Nelson as Dale Ballard | Wendie Malick as Linda Hagemeyer | Director : Jaffar Mahmood | |
| Air Date : Nov. 18, 2021 | Rating ➦ ★★★★★★ |
| Episode 8 - [The Grand Chancellor And A Den Of Sin] |
| Details : Sheldon battles President Hagemeyer's mysterious boss over the university's science requirements. Also Mary discovers that Georgie is working at Connie's illegal gambling room. |
| Guest Cast and Crew : Nikea Gamby-Turner as Florence | Valerie Gutierrez as Student #1 | Edwin Kho as Student #3 | Denisse Ojeda as Melissa | Zachary Alexander Rice as Zach | Ben Stillwell as Lyle | Kiana Thompson as Student #2 | Jared Wernick as Clark | Mary Kate Wiles as Patricia | Nancy Linehan Charles as Peg | Ed Begley Jr. as Grant Linkletter | Wendie Malick as Linda Hagemeyer | Director : Alex Reid | |
| Air Date : Dec. 02, 2021 | Rating ➦ ★★★★★★ |
| Episode 9 - [The Yips And An Oddly Hypnotic Bohemian] |
| Details : Sheldon gets the science yips and has to learn how to not think. Also George Sr. plays handyman at Brenda Sparks' house. |
| Guest Cast and Crew : Sean McClay as Umpire #2 | L. Emille Thomas as Umpire #1 | Craig T. Nelson as Dale Ballard | Ed Begley Jr. as Grant Linkletter | Rex Linn as Tom Petersen | Melissa Peterman as Brenda Sparks | Director : Kabir Akhtar | |
| Air Date : Dec. 09, 2021 | Rating ➦ ★★★★★★ |
| Episode 10 - [An Expensive Glitch And A Goof-Off Room] |
| Details : Sheldon gets a dorm room all to himself. Also Connie gains an unwanted business partner. |
| Guest Cast and Crew : Reba McEntire as June | Taylor Spreitler as Sam | Keanush Tafreshi as Matt | Aneasa Yacoub as Diane | Wallace Shawn as John Sturgis | Wendie Malick as Linda Hagemeyer | Grady Lee Richmond as Wade | Writer : Steven Molaro | Director : Melissa Joan Hart | Writer : Jeremy Howe | Writer : Eric Kaplan | Writer : Steve Holland | Writer : Connor Kilpatrick | Writer : Nadiya Chettiar | |
| Air Date : Jan. 06, 2022 | Rating ➦ ★★★★★★ |
| Episode 11 - [A Lock-In A Weather Girl And A Disgusting Habit] |
| Details : Sheldon acts as Mary's spy during a youth lock-in at church. Also Georgie is attracted to an older woman Mandy. |
| Guest Cast and Crew : Jully Lee as Chloe | Nancy Linehan Charles as Peg | Dan Byrd as Rob | Emily Osment as Mandy | Rex Linn as Tom Petersen | Melissa Peterman as Brenda Sparks | Director : Alex Reid | |
| Air Date : Jan. 13, 2022 | Rating ➦ ★★★★★★ |
| Episode 12 - [A Pink Cadillac And A Glorious Tribal Dance] |
| Details : Sheldon attends his first comic book convention; Mary tries selling makeup. |
| Guest Cast and Crew : Sarah Baker as Sheryl Hutchins | Jason Alexander as Gene Lundy | Steve Burns as Nathan | Jackie Geary as Ann | Brian Stepanek as Hubert Givens | Nancy Linehan Charles as Peg | Ed Begley Jr. as Grant Linkletter | Melissa Peterman as Brenda Sparks | Wendie Malick as Linda Hagemeyer | Director : Beth McCarthy-Miller | |
| Air Date : Jan. 20, 2022 | Rating ➦ ★★★★★★ |
| Episode 13 - [A Lot Of Band-Aids And The Cooper Surrender] |
| Details : Sheldon makes friends with his dorm neighbors; George Sr. learns his job is in jeopardy. |
| Guest Cast and Crew : Maddy Caddell as Abby | Caleb Emery as Darren | Ivan Mok as Oscar | Doc Farrow as Wayne Wilkins | Rex Linn as Tom Petersen | Director : Jaffar Mahmood | |
| Air Date : Jan. 27, 2022 | Rating ➦ ★★★★★★ |
| Episode 14 - [A Free Scratcher And Feminine Wiles] |
| Details : Sheldon butts heads with Dr. Lee a new scientist in the lab. Also Mary is given a lotto ticket. |
| Guest Cast and Crew : Derrick L. McMillon as Hal | Ming-Na Wen as Carol Lee | Wallace Shawn as John Sturgis | Ed Begley Jr. as Grant Linkletter | Rex Linn as Tom Petersen | Wendie Malick as Linda Hagemeyer | Director : Michael Judd | |
| Air Date : Feb. 24, 2022 | Rating ➦ ★★★★★★ |
| Episode 15 - [A Lobster An Armadillo And A Way Bigger Number] |
| Details : Sheldon joins Dr. Linkletter and Dr. Sturgis on a science road trip. Also Georgie continues to lie about his age. |
| Guest Cast and Crew : Wallace Shawn as John Sturgis | Craig T. Nelson as Dale Ballard | Emily Osment as Mandy | Ed Begley Jr. as Grant Linkletter | Wendie Malick as Linda Hagemeyer | Director : Alex Reid | |
| Air Date : Mar. 03, 2022 | Rating ➦ ★★★★★★★ |
| Episode 16 - [A Suitcase Full Of Cash And A Yellow Clown Car] |
| Details : Connie's gambling room is a success and Sheldon dips his toe in the stock market. Also Missy starts a business. |
| Air Date : Mar. 10, 2022 |
| Episode 17 - [A Solo Peanut A Social Butterfly And The Truth] |
| Details : Sheldon gets an odd request from an old friend Paige. Also George Sr. and Mary are caught in the middle of Connie and Dale's breakup and Georgie comes clean to Mandy. |
| Air Date : Mar. 31, 2022 |
| Episode 18 - [Babies Lies And A Resplendent Cannoli] |
| Details : Sheldon copes with the death of a hero. Also Missy wants to babysit and Georgie struggles with his big secret. |
| Air Date : Apr. 14, 2022 |
| Episode 19 - [A God-Fearin' Baptist And A Hot Trophy Husband] |
| Details : George and Mary insist on meeting the new woman in Georgie's life. Also Sheldon and Missy have suspicions about what's going on with their family. |
| Air Date : Apr. 21, 2022 |
| Episode 20 - [Uncle Sheldon And A Hormonal Firecracker] |
| Details : Sheldon and Missy learn about Georgie's pregnancy and the whole family promises to keep it a secret. |
| Air Date : Apr. 28, 2022 |
| Episode 21 - [White Trash Holy Rollers And Punching People] |
| Details : As the church congregation gossips about Georgie Missy stands up for her brother and Sheldon is distracted by the family drama. |
| Air Date : May. 12, 2022 |
| Episode 22 - [Clogged Pore A Little Spanish And The Future] |
| Details : Sheldon struggles to cope with the first signs of puberty. Also Mary and George Sr. hunt for new jobs and Georgie and Meemaw take a business trip across the border. |
| Air Date : May. 19, 2022 |